Use of Temperature-Sensitive and Cold-Adapted Mutant Viroses in Immunoprophylaxis of Acute Respiratory Tract Disease
Identifieur interne : 002787 ( Main/Exploration ); précédent : 002786; suivant : 002788Use of Temperature-Sensitive and Cold-Adapted Mutant Viroses in Immunoprophylaxis of Acute Respiratory Tract Disease
Auteurs : Robert M. Chanock [États-Unis] ; Brian R. Murphy [États-Unis]Source :
- Reviews of Infectious Diseases [ 1058-4838 ] ; 1980.
Abstract
Efforts currently are underway to develop mutations in the influenza A viral genome that will bring about a satisfactory level of attenuation and that can be identified by simple in vitro techniques. Two types of donor viruses that bear such mutations are being evaluated. One donor virus possesses temperature-sensitive (ts) mutations on the PI and P3 genes, while the other donor bears both ts and cold-adaptation (ca) mutations. The mutant genes from these donors were transferred by gene reassortment to recombinant viruses bearing the surface antigens of new epidemic or pandemic viruses, and in every instance a satisfactory level of attenuation was achieved. However, genetic instability remains a formidable problem. Temperature-sensitive mutants of respiratory syncytial virus also have been evaluated for their usefulness in immunoprophylaxisof respiratory tract disease. Although the desired mutant has not been identified, some progress has been made.
Url:
DOI: 10.1093/clinids/2.3.421
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000A77
- to stream Istex, to step Curation: 000A77
- to stream Istex, to step Checkpoint: 001401
- to stream Main, to step Merge: 002934
- to stream Main, to step Curation: 002787
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Use of Temperature-Sensitive and Cold-Adapted Mutant Viroses in Immunoprophylaxis of Acute Respiratory Tract Disease</title><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8D777537695A128A6D8008A44D99A92FD923D3FF</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1093/clinids/2.3.421</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-LXB1Q7KJ-M/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000A77</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000A77</idno><idno type="wicri:Area/Istex/Curation">000A77</idno><idno type="wicri:Area/Istex/Checkpoint">001401</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001401</idno><idno type="wicri:doubleKey">1058-4838:1980:Chanock R:use:of:temperature</idno><idno type="wicri:Area/Main/Merge">002934</idno><idno type="wicri:Area/Main/Curation">002787</idno><idno type="wicri:Area/Main/Exploration">002787</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Use of Temperature-Sensitive and Cold-Adapted Mutant Viroses in Immunoprophylaxis of Acute Respiratory Tract Disease</title><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Robert M. Chanock, Laboratory of Infectious Diseases, National Institute of Al1ergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Reviews of Infectious Diseases</title><title level="j" type="abbrev">Reviews of Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1980-05">1980</date><biblScope unit="vol">2</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="421">421</biblScope><biblScope unit="page" to="432">432</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Efforts currently are underway to develop mutations in the influenza A viral genome that will bring about a satisfactory level of attenuation and that can be identified by simple in vitro techniques. Two types of donor viruses that bear such mutations are being evaluated. One donor virus possesses temperature-sensitive (ts) mutations on the PI and P3 genes, while the other donor bears both ts and cold-adaptation (ca) mutations. The mutant genes from these donors were transferred by gene reassortment to recombinant viruses bearing the surface antigens of new epidemic or pandemic viruses, and in every instance a satisfactory level of attenuation was achieved. However, genetic instability remains a formidable problem. Temperature-sensitive mutants of respiratory syncytial virus also have been evaluated for their usefulness in immunoprophylaxisof respiratory tract disease. Although the desired mutant has not been identified, some progress has been made.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name></region><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002787 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002787 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8D777537695A128A6D8008A44D99A92FD923D3FF
|texte= Use of Temperature-Sensitive and Cold-Adapted Mutant Viroses in Immunoprophylaxis of Acute Respiratory Tract Disease
}}
| This area was generated with Dilib version V0.6.33. |  |